Increased Valency of Conserved-mosaic Vaccines Enhances the Breadth and Depth of Epitope Recognition

The biggest roadblock in development of effective vaccines against human immunodeficiency virus type 1 (HIV-1) is the virus genetic diversity. For T-cell vaccine, this can be tackled by focusing the vaccine-elicited T-cells on the highly functionally conserved regions of HIV-1 proteins, mutations in...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Abdul-Jawad, Sultan, Ondondo, Beatrice, van Hateren, Andy, Gardner, Andrew, Elliott, Tim, Korber, Bette, Hanke, Tomáš
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817818/
https://ncbi.nlm.nih.gov/pubmed/26581160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.210
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