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Increased Valency of Conserved-mosaic Vaccines Enhances the Breadth and Depth of Epitope Recognition

The biggest roadblock in development of effective vaccines against human immunodeficiency virus type 1 (HIV-1) is the virus genetic diversity. For T-cell vaccine, this can be tackled by focusing the vaccine-elicited T-cells on the highly functionally conserved regions of HIV-1 proteins, mutations in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther
Hauptverfasser: Abdul-Jawad, Sultan, Ondondo, Beatrice, van Hateren, Andy, Gardner, Andrew, Elliott, Tim, Korber, Bette, Hanke, Tomáš
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817818/
https://ncbi.nlm.nih.gov/pubmed/26581160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.210
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