SET1A Cooperates With CUDR to Promote Liver Cancer Growth and Hepatocyte-like Stem Cell Malignant Transformation Epigenetically

Long noncoding RNA CUDR plays an important role during tumorigenesis. Herein, we demonstrate that SET1A cooperates with CUDR to accelerate hepatocarcinogenesis and promote malignant transformation of hepatocyte-like stem cells. Mechanistically, CUDR enhances the phosphorylation of RB1, C-myc express...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Li, Tianming, Zheng, Qidi, An, Jiahui, Wu, Mengying, Li, Haiyan, Gui, Xin, Pu, Hu, Lu, Dongdong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817816/
https://ncbi.nlm.nih.gov/pubmed/26581161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.208
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