Characterization and Functional Analysis of scFv-based Chimeric Antigen Receptors to Redirect T Cells to IL13Rα2-positive Glioma

Immunotherapy with T cells expressing chimeric antigen receptors (CARs) is an attractive approach to improve outcomes for patients with glioblastoma (GBM). IL13Rα2 is expressed at a high frequency in GBM but not in normal brain, making it a promising CAR T-cell therapy target. IL13Rα2-specific CARs...

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Dettagli Bibliografici
Pubblicato in:Mol Ther
Autori principali: Krenciute, Giedre, Krebs, Simone, Torres, David, Wu, Meng-Fen, Liu, Hao, Dotti, Gianpietro, Li, Xiao-Nan, Lesniak, Maciej S, Balyasnikova, Irina V, Gottschalk, Stephen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817815/
https://ncbi.nlm.nih.gov/pubmed/26514825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.199
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