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Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector

Adeno-associated virus (AAV) has shown great promise as a gene therapy vector in multiple aspects of preclinical and clinical applications. Many developments including new serotypes as well as self-complementary vectors are now entering the clinic. With these ongoing vector developments, continued e...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Grieger, Joshua C, Soltys, Stephen M, Samulski, Richard Jude
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817810/
https://ncbi.nlm.nih.gov/pubmed/26437810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.187
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