Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we develop a mechanistic model for the synthesis of rAAV viral vectors by triple p...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Nguyen, Tam N.T., Sha, Sha, Hong, Moo Sun, Maloney, Andrew J., Barone, Paul W., Neufeld, Caleb, Wolfrum, Jacqueline, Springs, Stacy L., Sinskey, Anthony J., Braatz, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8143981/
https://ncbi.nlm.nih.gov/pubmed/34095346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.04.006
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados