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Genetic Modifiers of the p53 Pathway
The tumor suppressor gene TP53 is the most frequently mutated gene in human cancer; this gene is subject to inactivation by mutation or deletion in >50% of sporadic cancers. Genes that encode proteins that regulate p53 function, such as MDM2, MDM4, and CDKN2A (p14(ARF)) are also frequently altere...
שמור ב:
| הוצא לאור ב: | Cold Spring Harb Perspect Med |
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| Main Authors: | , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Cold Spring Harbor Laboratory Press
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4817744/ https://ncbi.nlm.nih.gov/pubmed/27037420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a026302 |
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