THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

Characterization of previously described intraflagellar transport (IFT) mouse mutants has led to the proposition that normal primary cilia are required for mammalian cells to respond to the sonic hedgehog (SHH) signal. Here we describe an N-ethyl-N-nitrosourea–induced mutant mouse, alien (aln), whic...

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Vydáno v:Nat Genet
Hlavní autoři: Tran, Pamela V, Haycraft, Courtney J, Besschetnova, Tatiana Y, Turbe-Doan, Annick, Stottmann, Rolf W, Herron, Bruce J, Chesebro, Allyson L, Qiu, Haiyan, Scherz, Paul J, Shah, Jagesh V, Yoder, Bradley K, Beier, David R
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817720/
https://ncbi.nlm.nih.gov/pubmed/18327258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.105
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