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Cholesterol Metabolism Is Required for Intracellular Hedgehog Signal Transduction In Vivo
We describe the rudolph mouse, a mutant with striking defects in both central nervous system and skeletal development. Rudolph is an allele of the cholesterol biosynthetic enzyme, hydroxysteroid (17-beta) dehydrogenase 7, which is an intriguing finding given the recent implication of oxysterols in m...
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| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2011
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164675/ https://ncbi.nlm.nih.gov/pubmed/21912524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002224 |
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