Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) comprises an emerging spectrum of inherited and noninherited disorders of the immune system characterized by the excessive production of cytokines, including interferon-γ and interleukins 2, 6, and 10 (IL-2, IL-6, and IL-10). The Janus kinases (JAKs) transduc...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Das, Rupali, Guan, Peng, Sprague, Leslee, Verbist, Katherine, Tedrick, Paige, An, Qi Angel, Cheng, Cheng, Kurachi, Makoto, Levine, Ross, Wherry, E. John, Canna, Scott W., Behrens, Edward M., Nichols, Kim E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817310/
https://ncbi.nlm.nih.gov/pubmed/26825707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-12-684399
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