Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) comprises an emerging spectrum of inherited and noninherited disorders of the immune system characterized by the excessive production of cytokines, including interferon-γ and interleukins 2, 6, and 10 (IL-2, IL-6, and IL-10). The Janus kinases (JAKs) transduc...

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Publicado en:Blood
Autores principales: Das, Rupali, Guan, Peng, Sprague, Leslee, Verbist, Katherine, Tedrick, Paige, An, Qi Angel, Cheng, Cheng, Kurachi, Makoto, Levine, Ross, Wherry, E. John, Canna, Scott W., Behrens, Edward M., Nichols, Kim E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2016
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817310/
https://ncbi.nlm.nih.gov/pubmed/26825707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-12-684399
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