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Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

Ceramide and complex sphingolipids regulate important cellular functions including cell growth, apoptosis, and signaling. Dysregulation of sphingolipid metabolism leads to pathological consequences such as sphingolipidoses and insulin resistance. Ceramides in mammals vary greatly in their acyl-chain...

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Publicado en:J Biol Chem
Main Authors: Sassa, Takayuki, Hirayama, Taisuke, Kihara, Akio
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817178/
https://ncbi.nlm.nih.gov/pubmed/26887952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.695858
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