Inhibition of mTOR activity in diabetes mellitus reduces proteinuria but not renal accumulation of hyaluronan

Objectives. Accumulation of extracellular matrix (ECM) components is an early sign of diabetic nephropathy. Also the glycosaminoglycan hyaluronan (HA) is elevated in the renal interstitium during experimental diabetes. The mammalian target of rapamycin (mTOR) pathway participates in the signaling of...

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Bibliographische Detailangaben
Veröffentlicht in:Ups J Med Sci
Hauptverfasser: Stridh, Sara, Palm, Fredrik, Takahashi, Tomoko, Ikegami-Kawai, Mayumi, Hansell, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Informa Healthcare 2015
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816883/
https://ncbi.nlm.nih.gov/pubmed/26175092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03009734.2015.1062442
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