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Inhibition of mTOR activity in diabetes mellitus reduces proteinuria but not renal accumulation of hyaluronan

Objectives. Accumulation of extracellular matrix (ECM) components is an early sign of diabetic nephropathy. Also the glycosaminoglycan hyaluronan (HA) is elevated in the renal interstitium during experimental diabetes. The mammalian target of rapamycin (mTOR) pathway participates in the signaling of...

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書誌詳細
出版年:Ups J Med Sci
主要な著者: Stridh, Sara, Palm, Fredrik, Takahashi, Tomoko, Ikegami-Kawai, Mayumi, Hansell, Peter
フォーマット: Artigo
言語:Inglês
出版事項: Informa Healthcare 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816883/
https://ncbi.nlm.nih.gov/pubmed/26175092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03009734.2015.1062442
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