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Inhibition of mTOR activity in diabetes mellitus reduces proteinuria but not renal accumulation of hyaluronan

Objectives. Accumulation of extracellular matrix (ECM) components is an early sign of diabetic nephropathy. Also the glycosaminoglycan hyaluronan (HA) is elevated in the renal interstitium during experimental diabetes. The mammalian target of rapamycin (mTOR) pathway participates in the signaling of...

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Bibliografski detalji
Izdano u:Ups J Med Sci
Glavni autori: Stridh, Sara, Palm, Fredrik, Takahashi, Tomoko, Ikegami-Kawai, Mayumi, Hansell, Peter
Format: Artigo
Jezik:Inglês
Izdano: Informa Healthcare 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816883/
https://ncbi.nlm.nih.gov/pubmed/26175092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03009734.2015.1062442
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