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mTOR inhibitors in renal cell carcinoma
The mammalian target of rapamycin (mTOR) is a downstream effector of the PI3-K/Akt/mTOR pathway. Allosteric inhibitors of mTOR, everolimus and temsirolimus, have shown promising clinical activity in advanced renal cell carcinoma but their effect is far from durable and only a subset of patients expe...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164983/ https://ncbi.nlm.nih.gov/pubmed/21894244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/thy.11.32 |
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