Delayed mTOR Inhibition with Low Dose of Everolimus Reduces TGFβ Expression, Attenuates Proteinuria and Renal Damage in the Renal Mass Reduction Model

BACKGROUND: The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migr...

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Autori principali: Kurdián, Melania, Herrero-Fresneda, Inmaculada, Lloberas, Nuria, Gimenez-Bonafe, Pepita, Coria, Virginia, Grande, María T., Boggia, José, Malacrida, Leonel, Torras, Joan, Arévalo, Miguel A., González-Martínez, Francisco, López-Novoa, José M., Grinyó, Josep, Noboa, Oscar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299670/
https://ncbi.nlm.nih.gov/pubmed/22427849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032516
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