Delayed mTOR Inhibition with Low Dose of Everolimus Reduces TGFβ Expression, Attenuates Proteinuria and Renal Damage in the Renal Mass Reduction Model

BACKGROUND: The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migr...

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主要な著者: Kurdián, Melania, Herrero-Fresneda, Inmaculada, Lloberas, Nuria, Gimenez-Bonafe, Pepita, Coria, Virginia, Grande, María T., Boggia, José, Malacrida, Leonel, Torras, Joan, Arévalo, Miguel A., González-Martínez, Francisco, López-Novoa, José M., Grinyó, Josep, Noboa, Oscar
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299670/
https://ncbi.nlm.nih.gov/pubmed/22427849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032516
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