Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling

AIMS: Mice deficient in IL-1 receptor 1 (hence unresponsive to both IL-1 isoforms α and β) have impaired expansive arterial remodeling due to diminished expression of matrix-degrading enzymes, especially MMP-3. Emergence of IL-1 as a target in cardiovascular disease prompted the investigation of the...

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Udgivet i:PLoS One
Main Authors: Beltrami-Moreira, Marina, Vromman, Amélie, Sukhova, Galina K., Folco, Eduardo J., Libby, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816548/
https://ncbi.nlm.nih.gov/pubmed/27032103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152474
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