Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML)

Cardiac glycosides (CGs), inhibitors of Na(+)/K(+)-ATPase (NKA), used clinically to treat heart failure, have garnered recent attention as potential anti-cancer and anti-viral agents. A high-throughput phenotypic screen designed to identify modulators of promyelocytic leukemia protein (PML) nuclear...

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Udgivet i:PLoS One
Main Authors: Milutinovic, Snezana, Heynen-Genel, Susanne, Chao, Elizabeth, Dewing, Antimone, Solano, Ricardo, Milan, Loribelle, Barron, Nikki, He, Min, Diaz, Paul W., Matsuzawa, Shu-ichi, Reed, John C., Hassig, Christian A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816303/
https://ncbi.nlm.nih.gov/pubmed/27031987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152692
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