Inhibition of Melanoma Growth by Small Molecules that Promote the Mitochondrial Localization of ATF2

PURPOSE: Effective therapy for malignant melanoma, the leading cause of death from skin cancer, remains an area of significant unmet need in oncology. The elevated expression of PKCε in advanced metastatic melanoma results in the increased phosphorylation of the transcription factor ATF2 on threonin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Varsano, Tal, Lau, Eric, Feng, Yongmei, Garrido, Marine, Milan, Loribelle, Heynen-Genel, Susanne, Hassig, Christian A., Ronai, Ze’ev A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690798/
https://ncbi.nlm.nih.gov/pubmed/23589174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2689
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