Inhibition of Melanoma Growth by Small Molecules that Promote the Mitochondrial Localization of ATF2

PURPOSE: Effective therapy for malignant melanoma, the leading cause of death from skin cancer, remains an area of significant unmet need in oncology. The elevated expression of PKCε in advanced metastatic melanoma results in the increased phosphorylation of the transcription factor ATF2 on threonin...

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Main Authors: Varsano, Tal, Lau, Eric, Feng, Yongmei, Garrido, Marine, Milan, Loribelle, Heynen-Genel, Susanne, Hassig, Christian A., Ronai, Ze’ev A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690798/
https://ncbi.nlm.nih.gov/pubmed/23589174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2689
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