PKCε regulates ATF2 availability to alter mitochondrial permeability following genotoxic stress

The transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in non-malignant skin cancer. Here we identify that ATF2 tumor suppressor function is determined by its ability to localize at the mitochondria, where it alters membrane permeability following geno...

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Autori principali: Lau, Eric, Kluger, Harriet, Varsano, Tal, Lee, KiYoung, Scheffler, Immo, Rimm, David L., Ideker, Trey, Ronai, Ze’ev A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615433/
https://ncbi.nlm.nih.gov/pubmed/22304920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.01.016
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