The new antihypertensive drug iptakalim activates ATP-sensitive potassium channels in the endothelium of resistance blood vessels

AIM: To investigate the mechanisms underlying the activation of ATP-sensitive potassium channels (K(ATP)) by iptakalim in cultured rat mesenteric microvascular endothelial cells (MVECs). METHODS: Whole-cell K(ATP) currents were recorded in MVECs using automated patch clamp devices. Nucleotides (ATP,...

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Bibliografiske detaljer
Udgivet i:Acta Pharmacol Sin
Main Authors: Wang, Su-yang, Cui, Wen-yu, Wang, Hai
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816240/
https://ncbi.nlm.nih.gov/pubmed/26592519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.97
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