Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer

Both 5-methylcytosine (5mC) and its oxidized form 5-hydroxymethylcytosine (5hmC) have been proposed to be involved in tumorigenesis. Because the readout of the broadly used 5mC mapping method, bisulfite sequencing (BS-seq), is the sum of 5mC and 5hmC levels, the 5mC/5hmC patterns and relationship of...

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Veröffentlicht in:Cell Res
Hauptverfasser: Chen, Ke, Zhang, Jing, Guo, Zhongqiang, Ma, Qin, Xu, Zhengzheng, Zhou, Yuanyuan, Xu, Ziying, Li, Zhongwu, Liu, Yiqiang, Ye, Xiongjun, Li, Xuesong, Yuan, Bifeng, Ke, Yuwen, He, Chuan, Zhou, Liqun, Liu, Jiang, Ci, Weimin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816137/
https://ncbi.nlm.nih.gov/pubmed/26680004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.150
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