Distal regulatory elements identified by methylation and hydroxymethylation haplotype blocks from mouse brain

BACKGROUND: 5-Hydroxymethylcytosine (5hmC) is an oxidation product of 5-methylcytosine (5mC), and adjacent CpG sites in mammalian genome can be co-methylated and co-hydroxymethylated due to the processivity of DNMT and TET enzymes. RESULTS: We applied TAB-seq and oxBS-seq to selectively detect 5hmC...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Ma, Qin, Xu, Zhengzheng, Lu, Huan, Xu, Ziying, Zhou, Yuanyuan, Yuan, Bifeng, Ci, Weimin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311040/
https://ncbi.nlm.nih.gov/pubmed/30594220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-018-0248-3
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