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Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing Ifng transcription

Unlike the well-defined T(H)2 cytokine locus, little is known regarding regulatory elements that govern expression of Ifng, which encodes the signature T(H)1 cytokine interferon-γ. Evolutionary analysis revealed that the murine Ifng locus diverges from the ancestral locus due to structural rearrange...

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Detalhes bibliográficos
Main Authors: Schoenborn, Jamie R., Dorschner, Michael, Sekimata, Masayuki, Santer, Deanna, Shnyreva, Maria, Fitzpatrick, David R., Stamatoyannopoulos, John A., Wilson, Christopher B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144744/
https://ncbi.nlm.nih.gov/pubmed/17546033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1474
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