Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer

It is well established that cancer-associated epigenetic repression occurs concomitant with CpG island hypermethylation and loss of nucleosomes at promoters, but the role of nucleosome occupancy and epigenetic reprogramming at distal regulatory elements in cancer is still poorly understood. Here, we...

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Detalles Bibliográficos
Main Authors: Taberlay, Phillippa C., Statham, Aaron L., Kelly, Theresa K., Clark, Susan J., Jones, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158760/
https://ncbi.nlm.nih.gov/pubmed/24916973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.163485.113
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