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Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer

It is well established that cancer-associated epigenetic repression occurs concomitant with CpG island hypermethylation and loss of nucleosomes at promoters, but the role of nucleosome occupancy and epigenetic reprogramming at distal regulatory elements in cancer is still poorly understood. Here, we...

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Detalhes bibliográficos
Main Authors: Taberlay, Phillippa C., Statham, Aaron L., Kelly, Theresa K., Clark, Susan J., Jones, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158760/
https://ncbi.nlm.nih.gov/pubmed/24916973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.163485.113
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