OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes

Recent epigenome-wide mapping studies describe nucleosome-depleted regions (NDRs) at transcription start sites and enhancers. However, these static maps do not address causality or the roles of NDRs in gene control, and their relationship to transcription factors and DNA methylation is not well unde...

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Main Authors: You, Jueng Soo, Kelly, Theresa K., De Carvalho, Daniel D., Taberlay, Phillippa C., Liang, Gangning, Jones, Peter A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167525/
https://ncbi.nlm.nih.gov/pubmed/21844352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111309108
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