MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors

MLN4924 (pevonedistat), an inhibitor of the Nedd8 activating enzyme (NAE), has exhibited promising clinical activity in acute myelogenous leukemia (AML). Here we demonstrate that MLN4924 induces apoptosis in AML cell lines and clinical samples via a mechanism distinct from those observed in other ma...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Knorr, K L B, Schneider, P A, Meng, X W, Dai, H, Smith, B D, Hess, A D, Karp, J E, Kaufmann, S H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816118/
https://ncbi.nlm.nih.gov/pubmed/26045051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.74
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