MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors

MLN4924 (pevonedistat), an inhibitor of the Nedd8 activating enzyme (NAE), has exhibited promising clinical activity in acute myelogenous leukemia (AML). Here we demonstrate that MLN4924 induces apoptosis in AML cell lines and clinical samples via a mechanism distinct from those observed in other ma...

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Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Differ
Egile Nagusiak: Knorr, K L B, Schneider, P A, Meng, X W, Dai, H, Smith, B D, Hess, A D, Karp, J E, Kaufmann, S H
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Original Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816118/
https://ncbi.nlm.nih.gov/pubmed/26045051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.74
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