D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold

A series of 3-substituted 5-hydroxy-1,2,4-triazin-6(1H)-one derivatives were designed and synthesized as a new class of D-amino acid oxidase (DAAO) inhibitors. Some of the newly synthesized derivatives showed potent inhibitory activity against human DAAO with IC(50) values in the nanomolar range. Am...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Hin, Niyada, Duvall, Bridget, Berry, James F., Ferraris, Dana V., Rais, Rana, Alt, Jesse, Rojas, Camilo, Slusher, Barbara S., Tsukamoto, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816084/
https://ncbi.nlm.nih.gov/pubmed/26965861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.02.068
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