Natural product-based synthesis of novel anti-infective isothiocyanate- and isoselenocyanate-functionalized amphilectane diterpenes

The marine natural product (−)-8,15-diisocyano-11(20)-amphilectene (1), isolated from the Caribbean sponge Svenzea flava, was used as scaffold to synthetize five new products, all of which were tested against laboratory strains of Plasmodium falciparum and Mycobacterium tuberculosis H(37)Rv. The sca...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem Lett
Asıl Yazarlar: Nieves, Karinel, Prudhomme, Jacques, Le Roch, Karine G., Franzblau, Scott G., Rodríguez, Abimael D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815908/
https://ncbi.nlm.nih.gov/pubmed/26748697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.12.080
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