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Natural product-based synthesis of novel anti-infective isothiocyanate- and isoselenocyanate-functionalized amphilectane diterpenes
The marine natural product (−)-8,15-diisocyano-11(20)-amphilectene (1), isolated from the Caribbean sponge Svenzea flava, was used as scaffold to synthetize five new products, all of which were tested against laboratory strains of Plasmodium falciparum and Mycobacterium tuberculosis H(37)Rv. The sca...
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| Udgivet i: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4815908/ https://ncbi.nlm.nih.gov/pubmed/26748697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.12.080 |
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