Synthesis and preliminary biological evaluation of a small library of hybrid compounds based on Ugi isocyanide multicomponent reactions with a marine natural product scaffold

A mixture-based combinatorial library of five Ugi adducts (4–8) incorporating known antitubercular and antimalarial pharmacophores was successfully synthesized, starting from the naturally occurring diisocyanide 3, via parallel Ugi four-center three-component reactions (U-4C-3CR). The novel α-acylam...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Avilés, Edward, Prudhomme, Jacques, Roch, Karine G. Le, Franzblau, Scott G., Chandrasena, Kevin, Mayer, Alejandro M. S., Rodríguez, Abimael D.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815915/
https://ncbi.nlm.nih.gov/pubmed/26421992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.09.033
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