A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours

BACKGROUND: The current biomarkers alpha-fetoprotein and human chorionic gonadotropin have limited sensitivity and specificity for diagnosing malignant germ-cell tumours (GCTs). MicroRNAs (miRNAs) from the miR–371–373 and miR–302/367 clusters are overexpressed in all malignant GCTs, and some of thes...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Murray, Matthew J, Bell, Emma, Raby, Katie L, Rijlaarsdam, Martin A, Gillis, Ad J M, Looijenga, Leendert H J, Brown, Helen, Destenaves, Benoit, Nicholson, James C, Coleman, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815809/
https://ncbi.nlm.nih.gov/pubmed/26671749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.429
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