Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells

SAHA is a class I HDAC/HDAC6 co-inhibitor and an autophagy inducer currently undergoing clinical investigations in breast cancer patients. However, the molecular mechanism of action of SAHA in breast cancer cells remains unclear. In this study, we found that SAHA is equally effective in targeting ce...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Lee, Jane Ying-Chieh, Kuo, Ching-Wen, Tsai, Shing-Ling, Cheng, Siao Muk, Chen, Shang-Hung, Chan, Hsiu-Han, Lin, Chun-Hui, Lin, Kun-Yuan, Li, Chien-Feng, Kanwar, Jagat R., Leung, Euphemia Y., Cheung, Carlos Chun Ho, Huang, Wei-Jan, Wang, Yi-Ching, Cheung, Chun Hei Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814469/
https://ncbi.nlm.nih.gov/pubmed/27065869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00081
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