Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells

SAHA is a class I HDAC/HDAC6 co-inhibitor and an autophagy inducer currently undergoing clinical investigations in breast cancer patients. However, the molecular mechanism of action of SAHA in breast cancer cells remains unclear. In this study, we found that SAHA is equally effective in targeting ce...

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Udgivet i:Front Pharmacol
Main Authors: Lee, Jane Ying-Chieh, Kuo, Ching-Wen, Tsai, Shing-Ling, Cheng, Siao Muk, Chen, Shang-Hung, Chan, Hsiu-Han, Lin, Chun-Hui, Lin, Kun-Yuan, Li, Chien-Feng, Kanwar, Jagat R., Leung, Euphemia Y., Cheung, Carlos Chun Ho, Huang, Wei-Jan, Wang, Yi-Ching, Cheung, Chun Hei Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814469/
https://ncbi.nlm.nih.gov/pubmed/27065869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00081
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