Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses

A common genetic alteration in acute myeloid leukemia is the internal tandem duplication (ITD) in FLT3, the receptor for cytokine FLT3 ligand (FLT3L). Constitutively active FLT3-ITD promotes the expansion of transformed progenitors, but also has pleiotropic effects on hematopoiesis. We analyzed the...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Lau, Colleen M., Nish, Simone A., Yogev, Nir, Waisman, Ari, Reiner, Steven L., Reizis, Boris
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813676/
https://ncbi.nlm.nih.gov/pubmed/26903243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150642
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