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Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy
Most tumor-associated antigens represent self-proteins and as a result are poorly immunogenic due to immune tolerance. Here we show that tolerance to carcinoembryonic antigen (CEA), which is overexpressed by the majority of lethal malignancies, can be reversed by immunization with a CEA-derived pept...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The National Academy of Sciences
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC37517/ https://ncbi.nlm.nih.gov/pubmed/11427731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.141226398 |
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