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Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses
A common genetic alteration in acute myeloid leukemia is the internal tandem duplication (ITD) in FLT3, the receptor for cytokine FLT3 ligand (FLT3L). Constitutively active FLT3-ITD promotes the expansion of transformed progenitors, but also has pleiotropic effects on hematopoiesis. We analyzed the...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4813676/ https://ncbi.nlm.nih.gov/pubmed/26903243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150642 |
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