Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO

AML1-ETO is the most common fusion oncoprotein causing acute myeloid leukemia (AML), a disease with a 5-year survival rate of only 24%. AML1-ETO functions as a rogue transcription factor, altering the expression of genes critical for myeloid cell development and differentiation. Currently, there are...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Roh, Soung-Hun, Kasembeli, Moses, Galaz-Montoya, Jesús G., Trnka, Mike, Lau, Wilson Chun-Yu, Burlingame, Alma, Chiu, Wah, Tweardy, David J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813495/
https://ncbi.nlm.nih.gov/pubmed/26706127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.684878
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