B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia

PAX5 is a transcription factor that is required for the development and maintenance of B cells. Promyelocytic leukemia (PML) is a tumor suppressor and proapoptotic factor. The fusion gene PAX5-PML has been identified in acute lymphoblastic leukemia with chromosomal translocation t(9;15)(p13;q24). We...

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Vydáno v:J Biol Chem
Hlavní autoři: Imoto, Naoto, Hayakawa, Fumihiko, Kurahashi, Shingo, Morishita, Takanobu, Kojima, Yuki, Yasuda, Takahiko, Sugimoto, Keiki, Tsuzuki, Shinobu, Naoe, Tomoki, Kiyoi, Hitoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813494/
https://ncbi.nlm.nih.gov/pubmed/26703467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.637835
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