GATA2 zinc finger 2 mutation found in acute myeloid leukemia impairs myeloid differentiation

We identified two novel GATA2 mutations in acute myeloid leukemia (AML). One mutation (p.R308P-GATA2) was a R308P substitution within the zinc finger (ZF)-1 domain, and the other (p.A350_N351ins8-GATA2) was an eight-amino-acid insertion between A350 and N351 residues within the ZF-2 domain. p.R308P-...

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Detalhes bibliográficos
Main Authors: Niimi, Keiko, Kiyoi, Hitoshi, Ishikawa, Yuichi, Hayakawa, Fumihiko, Kurahashi, Shingo, Kihara, Rika, Tomita, Akihiro, Naoe, Tomoki
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2013
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3850381/
https://ncbi.nlm.nih.gov/pubmed/24371770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lrr.2013.02.002
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