Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity

The complex of coagulation factor VIIa (FVIIa), a trypsin-like serine protease, and membrane-bound tissue factor (TF) initiates blood coagulation upon vascular injury. Binding of TF to FVIIa promotes allosteric conformational changes in the FVIIa protease domain and improves its catalytic properties...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Sorensen, Anders B., Madsen, Jesper J., Svensson, L. Anders, Pedersen, Anette A., Østergaard, Henrik, Overgaard, Michael T., Olsen, Ole H., Gandhi, Prafull S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Protein Structure and Folding
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813490/
https://ncbi.nlm.nih.gov/pubmed/26694616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698613
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