Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman

The sodium (Na(+))-calcium (Ca(2+)) exchanger 1 (NCX1) is an important regulator of intracellular Ca(2+) homeostasis. Serine 68-phosphorylated phospholemman (pSer-68-PLM) inhibits NCX1 activity. In the context of Na(+)/K(+)-ATPase (NKA) regulation, pSer-68-PLM is dephosphorylated by protein phosphat...

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Vydáno v:J Biol Chem
Hlavní autoři: Hafver, Tandekile Lubelwana, Hodne, Kjetil, Wanichawan, Pimthanya, Aronsen, Jan Magnus, Dalhus, Bjørn, Lunde, Per Kristian, Lunde, Marianne, Martinsen, Marita, Enger, Ulla Helene, Fuller, William, Sjaastad, Ivar, Louch, William Edward, Sejersted, Ole Mathias, Carlson, Cathrine Rein
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813481/
https://ncbi.nlm.nih.gov/pubmed/26668322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677898
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