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Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein

The prion protein (PrP) seems to exert both neuroprotective and neurotoxic activities. The toxic activities are associated with the C-terminal globular parts in the absence of the flexible N terminus, specifically the hydrophobic domain (HD) or the central region (CR). The wild type prion protein (P...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Nyeste, Antal, Bencsura, Petra, Vida, István, Hegyi, Zoltán, Homolya, László, Fodor, Elfrieda, Welker, Ervin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813475/
https://ncbi.nlm.nih.gov/pubmed/26721882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679035
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