Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein

The prion protein (PrP) seems to exert both neuroprotective and neurotoxic activities. The toxic activities are associated with the C-terminal globular parts in the absence of the flexible N terminus, specifically the hydrophobic domain (HD) or the central region (CR). The wild type prion protein (P...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Nyeste, Antal, Bencsura, Petra, Vida, István, Hegyi, Zoltán, Homolya, László, Fodor, Elfrieda, Welker, Ervin
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813475/
https://ncbi.nlm.nih.gov/pubmed/26721882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679035
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