Prion Protein Does Not Confer Resistance to Hippocampus-Derived Zpl Cells against the Toxic Effects of Cu(2+), Mn(2+), Zn(2+) and Co(2+) Not Supporting a General Protective Role for PrP in Transition Metal Induced Toxicity

The interactions of transition metals with the prion protein (PrP) are well-documented and characterized, however, there is no consensus on their role in either the physiology of PrP or PrP-related neurodegenerative disorders. PrP has been reported to protect cells from the toxic stimuli of metals....

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cingaram, Pradeep Kumar Reddy, Nyeste, Antal, Dondapati, Divya Teja, Fodor, Elfrieda, Welker, Ervin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591282/
https://ncbi.nlm.nih.gov/pubmed/26426582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139219
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