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Catalytic S(N)2′- and Enantioselective Allylic Substitution with a Diborylmethane Reagent and Application in Synthesis

A catalytic method for site- and enantioselective addition of commercially available di-B(pin)-methane to allylic phosphates is introduced (pin = pinacolato). Transformations may be facilitated by an NHC-Cu complex (NHC = N-heterocyclic carbene) and products obtained in 63–95% yield, 88:12 to >98...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Shi, Ying, Hoveyda, Amir H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813298/
https://ncbi.nlm.nih.gov/pubmed/26845488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201600309
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