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Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro k(cat) measurements

Turnover numbers, also known as k(cat) values, are fundamental properties of enzymes. However, k(cat) data are scarce and measured in vitro, thus may not faithfully represent the in vivo situation. A basic question that awaits elucidation is: how representative are k(cat) values for the maximal cata...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Davidi, Dan, Noor, Elad, Liebermeister, Wolfram, Bar-Even, Arren, Flamholz, Avi, Tummler, Katja, Barenholz, Uri, Goldenfeld, Miki, Shlomi, Tomer, Milo, Ron
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4812741/
https://ncbi.nlm.nih.gov/pubmed/26951675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514240113
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