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Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism

In metabolism research, thermodynamics is usually used to determine the directionality of a reaction or the feasibility of a pathway. However, the relationship between thermodynamic potentials and fluxes is not limited to questions of directionality: thermodynamics also affects the kinetics of react...

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Main Authors: Noor, Elad, Bar-Even, Arren, Flamholz, Avi, Reznik, Ed, Liebermeister, Wolfram, Milo, Ron
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930492/
https://ncbi.nlm.nih.gov/pubmed/24586134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003483
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