Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2

Selective targeting of the oxidative state, which is a tightly balanced fundamental cellular property, is an attractive strategy for developing novel anti-leukemic chemotherapeutics with potential applications in the treatment of acute myeloid leukemia (AML), a molecularly heterogeneous disease. Dim...

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Библиографические подробности
Опубликовано в: :Pharmaceuticals (Basel)
Главные авторы: Lapidus, Rena G., Carter-Cooper, Brandon A., Sadowska, Mariola, Choi, Eun Yong, Wonodi, Omasiri, Muvarak, Nidal, Natarajan, Karthika, Pidugu, Lakshmi S., Jaiswal, Anil, Toth, Eric A., Rassool, Feyruz V., Etemadi, Arash, Sausville, Edward A., Baer, Maria R., Emadi, Ashkan
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4812368/
https://ncbi.nlm.nih.gov/pubmed/26797621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph9010004
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